50 years after first use, we still do not know how the core treatments-atropine, oximes, and diazepam-should best be given. We describe the limited evidence that can guide therapy and the factors that should be considered when designing further clinical studies. Medical management is difficult, with case fatality generally more than 15%. Unintentional poisoning kills far fewer people but is a problem in places where highly toxic organophosphorus pesticides are available. Organophosphorus pesticide self-poisoning is an important clinical problem in rural regions of the developing world, and kills an estimated 200 000 people every year. The Lancet Regional Health – Western Pacific. The Lancet Regional Health – Southeast Asia.The Lancet Gastroenterology & Hepatology.
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